PE-22-28
Third-Party Tested · COA AvailablePE-22-28 10 mg is a synthetic heptapeptide used in laboratory research for TREK-1 potassium channel modulation studies. HPLC-purified for high analytical purity, it is suitable for investigating peptide-channel interaction and biochemical mechanisms.
- 99.9% Purity
- Research Grade
- COA Verified
- Third-Party Tested
- Certificate of Analysis available for every lot
- ≥99% purity, HPLC & mass-spec verified
- Ships from a U.S. facility — same-day before 12pm CT
- Secure checkout · Free shipping on orders $300+
Synthetic Peptide for Neuropharmacology Research
Technical Overview
PE-22-28 10mg is a synthetic peptide compound developed for laboratory research involving two-pore-domain potassium channel modulation, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying TREK-1 channel function, synaptic plasticity and mood-circuit signaling, and related biochemical mechanisms.
PE-22-28 is a heptapeptide fragment corresponding to the C-terminal 22-28 region of spadin, the propeptide released during sortilin maturation. It selectively inhibits the TREK-1 (KCNK2) two-pore-domain potassium channel, modulating neuronal excitability in preparations from cortex, hippocampus, and dorsal raphe.
Researchers employ PE-22-28 to probe TREK-1 contributions to fast-onset antidepressant signaling, neurogenesis, and serotonergic activity in rodent brain-slice and primary-culture models. Its relative ease of synthesis compared to full-length spadin makes it the preferred tool compound for TREK-1 antagonism studies.
This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.
Specifications
Compound Name: PE-22-28
Strength: 10mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.
Notice
Provided as a reference material for scientific investigation only.
Certificate of Analysis & Safety Data
Frequently Asked Questions
Is PE-22-28 third-party tested?
Yes. Every lot is independently third-party tested for identity and purity — ≥99% by HPLC and mass spectrometry — with a lot-matched Certificate of Analysis available to download on this page.
Can I see the Certificate of Analysis before buying?
Yes. A lot-matched COA is available on this product page and in our COA library before purchase, documenting identity, purity, and full analytical results.
What does 'Research Use Only' mean?
This product is supplied strictly for laboratory and research use only (RUO). It is not a drug, food, supplement, or cosmetic, is not approved by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease, or for human or veterinary consumption.
How is it shipped and stored?
Orders placed before 12pm CT typically ship the same business day from our U.S. facility with tracking. Store the lyophilized material at −20°C, protected from light and moisture.
