What is SELANK + SEMAX NASAL SPRAY?
Selank + Semax Nasal Spray pairs two structurally distinct synthetic peptides within a single laboratory preparation. Selank (CAS 129954-34-3) is a seven-residue peptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, molecular formula C33H57N11O9 and a molecular weight of 751.89. Semax (CAS 80714-61-0) is likewise a heptapeptide, sequence Met-Glu-His-Phe-Pro-Gly-Pro, with molecular formula C37H51N9O10S and molecular weight 813.93. Each is a short-chain oligopeptide constructed from standard L-amino acids; Semax is distinguished by a sulfur-bearing methionine residue at its N-terminus, which is reflected in its formula.
Both compounds belong to the class of proline-rich regulatory peptides derived from the study of endogenous peptide fragments. Selank is structurally related to the tetrapeptide tuftsin motif (Thr-Lys-Pro-Arg) extended with a stabilizing Pro-Gly-Pro sequence, while Semax is an analog associated with an ACTH-fragment lineage. The proline and glycine residues shared by both sequences contribute conformational rigidity and influence backbone folding and enzymatic-stability characteristics that are of interest in peptide-chemistry research.
These peptides are studied in neuropeptide and peptide-chemistry research contexts, where short regulatory sequences are examined as model systems for structure-activity relationships, in-vitro receptor and binding assays, and stability profiling. This product is intended strictly for laboratory research use. It is not a drug, supplement, or article for human or veterinary use, and the material is characterized here only in terms of its molecular identity, physical handling, and analytical verification — not any physiological activity.
Reconstitution & handling
When supplied in a nasal-spray format, the material may be presented as an aqueous peptide solution or as lyophilized powder intended for dissolution into a carrier solution prior to use in bench work. For lyophilized peptide, reconstitution is typically performed with bacteriostatic or sterile water; both Selank and Semax are hydrophilic, proline-rich sequences that generally exhibit good aqueous solubility owing to their charged and polar residues (the lysine and arginine of Selank and the glutamate and histidine of Semax). Solvent should be introduced slowly down the interior wall of the vial and allowed to dissolve by gentle swirling rather than vigorous shaking or vortexing, which can promote foaming, shear stress, and aggregation of peptide chains.
The methionine residue in Semax is oxidation-sensitive, so reconstituted solutions should be prepared in clean glassware, minimizing headspace exposure and prolonged contact with air. Solutions should be kept cold during handling, protected from light where practical, and used or aliquoted promptly. All reconstitution described here is chemical handling guidance for laboratory preparation only and does not constitute any use, dosing, or administration instruction.
Storage & stability
In lyophilized form, both peptides are most stable stored desiccated at −20°C, where a well-sealed vial protected from moisture and light retains integrity over extended periods. Once dissolved, aqueous peptide solutions are markedly less stable: they should be refrigerated at 2–8°C for short-term handling and held at −20°C or below for longer intervals, ideally in single-use aliquots to avoid repeated freeze-thaw cycles that degrade peptide chains. Because Semax carries an oxidation-prone methionine, minimizing exposure to air, elevated temperature, and light is particularly important for preserving the analytical purity of the combined preparation.
How it's tested
Identity and purity are established by reversed-phase high-performance liquid chromatography (HPLC), which resolves each peptide and quantifies chromatographic purity at ≥99% for the material. Molecular identity is confirmed by mass spectrometry (typically ESI-MS or MALDI-TOF), with observed masses cross-checked against the theoretical molecular weights of 751.89 for Selank and 813.93 for Semax to verify correct sequence assembly and the absence of truncated or oxidized species. A Certificate of Analysis (COA) documenting HPLC purity, mass-spectrometric confirmation, and lot-specific results is available for the product, providing traceable analytical verification for research recordkeeping.