What is KISSPEPTIN-10?
Kisspeptin-10 is a short synthetic peptide belonging to the kisspeptin family, a group of neuropeptides encoded by the KISS1 gene. As indicated by its name, it is a decapeptide (ten amino acid residues) representing the biologically conserved C-terminal fragment shared by the longer kisspeptin isoforms. Like other members of this family, it terminates in an amidated C-terminus, a structural feature characteristic of the RFamide peptide class to which kisspeptins belong.
Structurally, Kisspeptin-10 is produced by solid-phase peptide synthesis and purified to a research-grade standard. It is an amphipathic peptide of modest molecular size, supplied as a lyophilized (freeze-dried) powder. Its compact ten-residue architecture makes it a well-defined, reproducible reference molecule for in-vitro and preclinical laboratory work, and its identity and purity are confirmed by chromatographic and spectrometric analysis prior to release.
In the scientific literature, kisspeptins and their C-terminal fragments are studied as endogenous ligands of the KISS1R (GPR54) receptor and are used as tool compounds in reproductive neuroendocrinology and receptor-signaling research. Kisspeptin-10 is offered here strictly as a reference material for such in-vitro and laboratory investigations. This listing makes no therapeutic, physiological, or performance claims of any kind; the peptide is intended for laboratory research use only and is not a drug, food, or cosmetic.
Reconstitution & handling
Kisspeptin-10 is supplied as a lyophilized solid and must be brought into solution before use in laboratory work. Bacteriostatic or sterile water is a common reconstitution solvent for peptides of this class; for peptides that resist dissolution, a small volume of dilute acetic acid or another appropriate co-solvent is sometimes used first to aid initial dissolution before dilution into the working buffer. Solvent should be directed against the wall of the vial and allowed to contact the powder gently rather than forcefully injected onto it, and the vial should be swirled or left to stand rather than vortexed, since aggressive agitation can promote aggregation, foaming, or shear-related degradation.
Solubility and stability of the reconstituted material depend on solvent choice, concentration, and pH, and researchers should confirm compatibility with their specific downstream assay. Once reconstituted, the peptide is generally less stable than the dry powder and is best prepared fresh or divided into single-use aliquots to avoid repeated handling. Any figures relating to concentration are experimental parameters determined by the end user's protocol; this page provides chemistry and handling context only and contains no administration or dosing guidance.
Storage & stability
In lyophilized form, Kisspeptin-10 is most stable when stored sealed, protected from light and moisture, and kept frozen; short periods at refrigerated or ambient temperature during shipping are typically tolerated, but long-term storage at -20 C or colder is preferred to preserve integrity. After reconstitution, the peptide should be held refrigerated for short-term use or frozen in single-use aliquots for longer storage, and repeated freeze-thaw cycles should be minimized because they can accelerate hydrolysis and aggregation. Labeling aliquots with preparation dates and avoiding unnecessary warming help maintain the material's analytical quality over the course of a research program.
How it's tested
Each lot of Kisspeptin-10 is characterized analytically before release. Purity is determined by reversed-phase high-performance liquid chromatography (HPLC), with this material meeting a specification of ≥99% by HPLC. Identity is confirmed by mass spectrometry (MS), which verifies that the measured mass corresponds to the expected peptide, while HPLC peak integration quantifies chromatographic purity and resolves related-substance impurities. These results are documented on a lot-specific Certificate of Analysis (COA), which is available for the product and serves as the primary record of identity, purity, and quality for laboratory reference and record-keeping.